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ApHCC HYPP Bylaws, Policy & Procedure

* What is HYPP?
* ApHCC Genetic Disorders Bylaw
* ApHCC HYPP Policy & Procedure
* ApHCC Approved Laboratories for HYPP Testing

What is HYPP?

In 1986, veterinarian Jon Naylor (BVSc'75(Bristol), DiplACVIM'81 (Diplomate), PhD'84 (Pennsylvania), ACVN'88 (American College)) was one of the researchers who discovered a new disease of Quarter horses, Hyperkalemic Periodic Paralysis (HYPP). In 1992, Prof. Naylor and his colleagues proved that the disease is a genetic condition and that all known cases of HYPP have descended from one Quarter horse sire, Impressive. At the University of California at the Davis School of Veterinary Medicine, Dr. Sharon Spier was also researching HYPP. In November of 1992, following a presentation at the Association of Equine Practitioners meeting, Dr. Spier announced that in her research all horse found with the disease were descendants of the Quarter Horse stallion Impressive.

In simple terms, Hyperkalemic Periodic Paralysis (HYPP) is a muscular disease caused by a hereditary genetic defect which affects the muscle cells' balance of sodium and potassium.

"Horses with HYPP can experience unpredictable attacks of paralysis which, in severe cases, can lead to collapse and sudden death. The cause of death usually is cardiac arrest and/or respiratory failure. The disease is characterized by intermittent episodes of muscle tremors manifested by generalized of localized shaking, trembling and weakness. Occasionally, episodes are accompanied by respiratory noises resulting from paralysis of the muscles of the upper airway (larynx and pharynx). In cases of mild attacks, muscle tremors may be so subtle as to be detectable only by an experience clinician performing EMG testing."
from Current Facts About Hyperkalemic Periodic Paralysis (HYPP) Disease, Sharon J. Spier, DVM, PhD University of California at Davis School of Veterinary Medicine, Department of Medicine.

For further information please contact:

University of Saskatchewan

University of California at Davis


ApHCC Genetic Disorders Bylaw
ApHCC BYLAWS, SECTION XI - UNACCEPTABLE BREEDING AND/OR CHARACTERISTICS

C. Genetic Disorders

1. Effective 01 January 2000, any horse applying for identification or registration in the Register of Appaloosa Horses and carrying a known and/or identified genetic disorder, including, but not limited to, HYPP (Hyperkalemic Periodic Paralysis) and SCID (Severe Combined Immunodeficiency), shall only be eligible for entry into the Register of Appaloosa Horses upon receipt by the ApHCC of Application for Pedigree Registration/Identification and veterinary verification that the horse is a gelding or spayed mare.

2. Effective 01 January 2002,any horse applying for identification or registration in the Register of Appaloosa Horses and carrying a known and/or identified genetic disorder, including, but not limited to, HYPP (Hyperkalemic Periodic Paralysis) and SCID (Severe Combined Immunodeficiency), shall be denied identification or registration with the ApHCC.

3. Any ApHCC applicant or registered horse may be required, at the sole discretion of the ApHCC, to undergo testing to screen for any genetic disorder. Such testing will be performed by an ApHCC Authorized Representative, at the owner's expense, and the findings noted on the horse's certificate.

4. Failure of an owner to comply with a request of the ApHCC for such testing will result in the rejection of the Application for Pedigree Registration/Identification or withdrawing of registration/identification status of the horse. Such non-compliance may further be subject to review by the ApHCC Law Review Committee.


ApHCC HYPP Policy & Procedure

Hyperkalemic Periodic Paralysis (HYPP)
Bylaws, Section XI C. Genetic Disorders

A) HYPP Testing of Registered Horses

1. Any HYPP test results of a registered horse, issued prior to 1 June 2000 will be accepted by the ApHCC

2. Any HYPP test results of a registered horse, issued after 1 June 2000 will be accepted by the ApHCC if issued by an ApHCC approved laboratory.

3. A "registered" horse as referred to in items A) 1. and 2. may be:

* An Appaloosa for which an ApHCC Certificate of Registration or Certificate of Pedigree was issued prior to 1 January 1999

* An Appaloosa for which an ApHCC Certificate of Identification has been issued.

* All Appaloosa horses for which an ApHC (Moscow, Idaho) Certificate of Registration has been issued and which horses do not have Arabian parents or unknown parents

* All Quarter Horses for which an American Quarter Horse Association Certificate of Registration or Appendix Certificate or Canadian Quarter Horse Certificate of Registration has been issued

* All Thoroughbred horses for which a Jockey Club, Kentucky, or Canadian Thoroughbred Society Certificate of Registration has been issued.

B) HYPP Testing of Unregistered Horses

1. An unregistered horse may be HYPP tested prior to application for pedigree registration with the ApHCC provided the following procedures are followed:

* At this time, testing must be completed at the University of Calgary, Animal Genetics Laboratory, Vita-Tech Canada, or Maxxam Equitest.

* Samples must be collected and submitted by a veterinarian who must identify the animal, label the specimen, and sign the submission form.

* The veterinarian must use an Equine Infectious Anemia (EIA) Serum Test and Report form (Agriculture Form for Coggins) completely filled in and signed by the veterinatian but marked at the top: FOR HYPP (this reminds you that the sample was sent for HYPP and not for EIA (University of Calgary Animal Genetics Laboratory does not do Coggins tests)

* Two copies of the Equine Infectious Anemia submission form (FOR HYPP) shall accompany the specimen. One copy will be returned with the lab report.

* Should the owner choose to apply for ApHCC registration, the completed Application for Pedigree Registration form, required photographs, registration fees, AND the copy of the HYPP report including the copy of the EIA form returned from the lab shall be submitted to the ApHCC.

ApHCC Approved Laboratories for HYPP Testing

* As of 24 May 2000, only the University of Calgary Animal Genetics Laboratory, Vita-Tech Canada, and Maxxam Equitest have been ApHCC approved for testing of unregistered horses. Research is underway to determine if other laboratories performing HYPP testing will utilize the Equine Infectious Anemia form (FOR HYPP) for identification purposes when testing unregistered horses.

* As of 28 March 2000, the following laboratories have been ApHCC approved for HYPP testing of registered horses:

o University of Calgary Animal Genetics Laboratory, Calgary, Alberta
o Maxxam Equitest, Guelph, Ontario
o Vita-Tech Canada, Markham, Ontario
o University of California, Davis, California
o Stormont Laboratories, Woodland, California

The horse's registration number must be included on the submission forms as well as the results of the HYPP test.
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